Sporadic inclusion body myositis: evidence of a link between inflammation, cell stress and beta-amyloid deposition.

نویسنده

  • Frank Mastaglia
چکیده

http://jnnp.bmj.com/content/80/12/1301.full.html Updated information and services can be found at: These include: References http://jnnp.bmj.com/content/80/12/1301.full.html#ref-list-1 This article cites 6 articles, 2 of which can be accessed free at: service Email alerting box at the top right corner of the online article. Receive free email alerts when new articles cite this article. Sign up in the Topic collections

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منابع مشابه

Inclusion body myositis: new insights into pathogenesis.

PURPOSE OF REVIEW The pathogenesis of sporadic inclusion body myositis is complex and the disease has a relentless course. Recent observations regarding possible mechanisms of disease may provide targets for therapy. RECENT FINDINGS Evidence is strengthening that specific T-cell and B-cell responses are ongoing in skeletal muscle in sporadic inclusion body myositis and that cytokines and chem...

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Inclusion-body myositis, a multifactorial muscle disease associated with aging: current concepts of pathogenesis.

PURPOSE OF REVIEW Sporadic inclusion-body myositis, the most common muscle disease of older persons, has no known cause or persistently beneficial treatment. The unfolding pathogenesis could lead to new treatment strategies and it is now of growing interest among clinicians and basic scientists. About 100 papers related to the subject were published in 2006 and the first part of 2007 (we cite o...

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Inflammatory muscle diseases: a critical review on pathogenesis and therapies.

Based on unique clinicopathological criteria, the most common immune inflammatory muscle disorders include Dermatomyositis (DM), Polymyositis (PM), Necrotizing Myositis (NM), and sporadic Inclusion Body Myositis (sIBM). DM is an undeniably a complement-mediated microangiopathy with destruction of capillaries, hypoperfusion, and inflammatory cell stress on the perifascicular regions. Necrotizing...

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Inclusion-Body Myositis Associated with Alzheimer's Disease

Sporadic inclusion-body myositis (s-IBM) is a myopathy that is characterized by progressive weakness and muscle pathology demonstrating inflammation and rimmed vacuoles. In addition, similar to the pathology observed in the brains of patients with Alzheimer's disease, the deposition of beta-amyloid and phosphorylated tau proteins in muscle fibers has been reported. These shared pathologic featu...

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Interrelation of inflammation and APP in sIBM: IL-1β induces accumulation of β-amyloid in skeletal muscle

Distinct interrelationships between inflammation and beta-amyloid-associated degeneration, the two major hallmarks of the skeletal muscle pathology in sporadic inclusion body myositis (sIBM), have remained elusive. Expression of markers relevant for these pathomechanisms were analysed in biopsies of sIBM, polymyositis (PM), dermatomyositis (DM), dystrophic and non-myopathic muscle as controls, ...

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عنوان ژورنال:
  • Journal of neurology, neurosurgery, and psychiatry

دوره 80 12  شماره 

صفحات  -

تاریخ انتشار 2009